The rapper/poet/actor guest stars on House tonight.

Now that ER is finally going off the air, where are big-name actors going to go to do one-episode stints as hospital patients suffering from some horrible disease?  House, of course!  In tonight’s episode (which airs at 8pm on FOX), Mos Def checks into the Princeton-Plainsboro Teaching Hospital as a man suffering from “locked-in syndrome”–when a person is conscious but their body is completely paralyzed, leaving them unable to move or speak.  Much of the episode is apparently shot from Mos’ perspective and we hear his thoughts about what he’s seeing and experiencing via a voiceover.  The episode has already earned a rave review from TV Guide and E! has posted a bunch of clips that look pretty great.  A full teaser trailer is below.